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Target
Renin
Ligand
BDBM50328856
Substrate
n/a
Meas. Tech.
ChEMBL_673944 (CHEMBL1275121)
IC50
0.11±n/a nM
Citation
 Corminboeuf, O; Bezençon, O; Grisostomi, C; Remen, L; Richard-Bildstein, S; Bur, D; Prade, L; Hess, P; Strickner, P; Fischli, W; Steiner, B; Treiber, A Design and optimization of new piperidines as renin inhibitors. Bioorg Med Chem Lett 20:6286-90 (2010) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50328856
Synonyms:
(3R,4S)-N-(2-chloro-5-(3-(methylamino)-3-oxopropyl)benzyl)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-3-carboxamide | CHEMBL1269683
Type:
Small organic molecule
Emp. Form.:
C35H40Cl3N3O4
Mol. Mass.:
673.069
SMILES:
CNC(=O)CCc1ccc(Cl)c(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c1 |r|
Structure:
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