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Target
Bcl-2-like protein 1
Ligand
BDBM50329370
Substrate
n/a
Meas. Tech.
ChEMBL_675632 (CHEMBL1273940)
Kd
5000000±n/a nM
Citation
 Petros, AM; Huth, JR; Oost, T; Park, CM; Ding, H; Wang, X; Zhang, H; Nimmer, P; Mendoza, R; Sun, C; Mack, J; Walter, K; Dorwin, S; Gramling, E; Ladror, U; Rosenberg, SH; Elmore, SW; Fesik, SW; Hajduk, PJ Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett 20:6587-91 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50329370
Synonyms:
4-(dimethylamino)-1,1-diphenylbutan-1-ol | CHEMBL1269479
Type:
Small organic molecule
Emp. Form.:
C18H23NO
Mol. Mass.:
269.3813
SMILES:
CN(C)CCCC(O)(c1ccccc1)c1ccccc1
Structure:
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