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Target
Bcl-2-related protein A1
Ligand
BDBM39162
Substrate
n/a
Meas. Tech.
ChEMBL_676082 (CHEMBL1273076)
IC50
1200±n/a nM
Citation
 Cashman, JR; MacDonald, M; Ghirmai, S; Okolotowicz, KJ; Sergienko, E; Brown, B; Garcia, X; Zhai, D; Dahl, R; Reed, JC Inhibition of Bfl-1 with N-aryl maleimides. Bioorg Med Chem Lett 20:6560-4 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM39162
Synonyms:
3-chloranyl-1-(3,4-dichlorophenyl)-4-[4-(3-methoxyphenyl)piperazin-1-yl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-(3-methoxyphenyl)piperazin-1-yl)-1H-pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[4-(3-methoxyphenyl)-1-piperazinyl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[4-(3-methoxyphenyl)piperazin-1-yl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[4-(3-methoxyphenyl)piperazino]-3-pyrroline-2,5-quinone | CHEMBL1272210 | MLS-0090882.0001 | cid_16654677
Type:
Small organic molecule
Emp. Form.:
C21H18Cl3N3O3
Mol. Mass.:
466.745
SMILES:
COc1cccc(c1)N1CCN(CC1)C1=C(Cl)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1 |c:16|
Structure:
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