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Target
Bcl-2-related protein A1
Ligand
BDBM39142
Substrate
n/a
Meas. Tech.
ChEMBL_676083 (CHEMBL1273077)
IC50
11100±n/a nM
Citation
 Cashman, JR; MacDonald, M; Ghirmai, S; Okolotowicz, KJ; Sergienko, E; Brown, B; Garcia, X; Zhai, D; Dahl, R; Reed, JC Inhibition of Bfl-1 with N-aryl maleimides. Bioorg Med Chem Lett 20:6560-4 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM39142
Synonyms:
1-[2,6-bis(chloranyl)-3-methyl-phenyl]-3-chloranyl-4-(4-methylpiperazin-1-yl)pyrrole-2,5-dione | 3-chloro-1-(2,6-dichloro-3-methyl-phenyl)-4-(4-methylpiperazino)-3-pyrroline-2,5-quinone | 3-chloro-1-(2,6-dichloro-3-methylphenyl)-4-(4-Methylpiperazin-1-yl)-1H-pyrrole-2,5-dione | 3-chloro-1-(2,6-dichloro-3-methylphenyl)-4-(4-methyl-1-piperazinyl)pyrrole-2,5-dione | 3-chloro-1-(2,6-dichloro-3-methylphenyl)-4-(4-methylpiperazin-1-yl)pyrrole-2,5-dione | CHEMBL1271824 | MLS-0090832.0001 | cid_16654639
Type:
Small organic molecule
Emp. Form.:
C16H16Cl3N3O2
Mol. Mass.:
388.676
SMILES:
CN1CCN(CC1)C1=C(Cl)C(=O)N(C1=O)c1c(Cl)ccc(C)c1Cl |c:8|
Structure:
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