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Target
Bcl-2-related protein A1
Ligand
BDBM50313365
Substrate
n/a
Meas. Tech.
ChEMBL_676083 (CHEMBL1273077)
IC50
1000±n/a nM
Citation
 Cashman, JR; MacDonald, M; Ghirmai, S; Okolotowicz, KJ; Sergienko, E; Brown, B; Garcia, X; Zhai, D; Dahl, R; Reed, JC Inhibition of Bfl-1 with N-aryl maleimides. Bioorg Med Chem Lett 20:6560-4 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM50313365
Synonyms:
(2R,3R,4S,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylbenzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | CHEMBL1085188
Type:
Small organic molecule
Emp. Form.:
C23H30O6
Mol. Mass.:
402.4807
SMILES:
CCc1ccc(Cc2cc(CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2C)cc1 |r|
Structure:
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