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Target
Bcl-2-related protein A1
Ligand
BDBM39147
Substrate
n/a
Meas. Tech.
ChEMBL_676083 (CHEMBL1273077)
IC50
800±n/a nM
Citation
 Cashman, JR; MacDonald, M; Ghirmai, S; Okolotowicz, KJ; Sergienko, E; Brown, B; Garcia, X; Zhai, D; Dahl, R; Reed, JC Inhibition of Bfl-1 with N-aryl maleimides. Bioorg Med Chem Lett 20:6560-4 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM39147
Synonyms:
3-chloranyl-1-(3,4-dichlorophenyl)-4-[(3R)-3-methylpiperazin-1-yl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(R)-3-methylpyperazin-1-yl)-1H-pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[(3R)-3-methyl-1-piperazinyl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[(3R)-3-methylpiperazin-1-yl]pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-[(3R)-3-methylpiperazino]-3-pyrroline-2,5-quinone | CHEMBL1272047 | MLS-0090857.0001 | cid_16654653
Type:
Small organic molecule
Emp. Form.:
C15H14Cl3N3O2
Mol. Mass.:
374.65
SMILES:
C[C@@H]1CN(CCN1)C1=C(Cl)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1 |c:8|
Structure:
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