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Target
NADPH oxidase 4
Ligand
BDBM50330703
Substrate
n/a
Meas. Tech.
ChEMBL_685143 (CHEMBL1286959)
Ki
240±n/a nM
Citation
 Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem 53:7715-30 (2010) [PubMed]  Article 
Target
Name:
NADPH oxidase 4
Synonyms:
KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase
Type:
PROTEIN
Mol. Mass.:
66954.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792879
Residue:
578
Sequence:
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
  
Inhibitor
Name:
BDBM50330703
Synonyms:
1-acetyl-2-(2-chlorophenyl)-4-methyl-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1277850
Type:
Small organic molecule
Emp. Form.:
C21H17ClN4O3
Mol. Mass.:
408.838
SMILES:
CC(=O)n1n(-c2ccccc2Cl)c(=O)c2c(C)n(Cc3cccnc3)c(=O)cc12 |(50.73,-44.13,;49.97,-42.79,;48.42,-42.78,;50.74,-41.46,;49.84,-40.21,;48.3,-40.21,;47.54,-41.54,;46,-41.55,;45.22,-40.21,;46,-38.87,;47.54,-38.88,;48.31,-37.54,;50.75,-38.97,;50.27,-37.5,;52.21,-39.45,;53.54,-38.67,;53.53,-37.13,;54.88,-39.43,;56.21,-38.66,;57.55,-39.42,;57.55,-40.96,;58.88,-41.73,;60.22,-40.95,;60.21,-39.4,;58.87,-38.64,;54.88,-40.99,;56.22,-41.75,;53.55,-41.76,;52.21,-40.99,)|
Structure:
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