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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50330931
Substrate
n/a
Meas. Tech.
ChEMBL_683924 (CHEMBL1286020)
Ki
>800±n/a nM
Citation
 Banerjee, A; Schepmann, D; Köhler, J; Würthwein, EU; Wünsch, B Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists. Bioorg Med Chem 18:7855-67 (2010) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50330931
Synonyms:
(+/-)-(2RS,4RS)-2-[(4RS)-2,2-Diphenyl-1,3-dioxolan-4-yl]-4-fluoropiperidine | (+/-)-(2RS,4RS)-2-[(4SR)-2,2-Diphenyl-1,3-dioxolan-4-yl]-4-fluoropiperidine | CHEMBL1163701 | rac-4-fluorodioxadrol
Type:
Small organic molecule
Emp. Form.:
C20H22FNO2
Mol. Mass.:
327.3926
SMILES:
FC1CCNC(C1)C1COC(O1)(c1ccccc1)c1ccccc1
Structure:
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