Reaction Details Report a problem with these data
Target
Zn finger protein
Ligand
BDBM50332023
Substrate
n/a
Meas. Tech.
ChEMBL_687568 (CHEMBL1290840)
Ki
77700±n/a nM
Citation
 Maresca, A; Scozzafava, A; Supuran, CT 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. Bioorg Med Chem Lett 20:7255-8 (2010) [PubMed]  Article 
Target
Name:
Zn finger protein
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
25827.13
Organism:
Nicotiana tabacum
Description:
ChEMBL_687568
Residue:
234
Sequence:
LPLPFFNMDTSHWPQGIGLAKAVEPSKPVPVTERKPRPQKEQAINCPRCNSTNTKFCYYNNYSLSQPRYFCKTCRRYWTDGGSLRNVPVGGGSRKNKRSNSSSNNSSSSTSSSYKKIPDLTIPTSSSTQNPKIINEPHDLNLTFNPSTTSNFSNISEFMALPLMNPNSTTSFMSSIMPQISDSNNIMYSSSSTGLPNLHDLKPTLNFSLDGFDNNNGYGSLQGETAGAKLFFPL
  
Inhibitor
Name:
BDBM50332023
Synonyms:
6-Acetyl-7-(2-adamantan-1-yl-ethoxy)-chromen-2-one | CHEMBL1290110
Type:
Small organic molecule
Emp. Form.:
C23H26O4
Mol. Mass.:
366.4501
SMILES:
CC(=O)c1cc2ccc(=O)oc2cc1OCCC12CC3CC(CC(C3)C1)C2 |TLB:26:17:24:21.20.22,THB:26:21:17.18.25:24,22:21:18:25.23.24,22:23:18:26.21.20,16:17:24:21.20.22|
Structure:
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