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Target
Triosephosphate isomerase, glycosomal
Ligand
BDBM50332792
Substrate
n/a
Meas. Tech.
ChEMBL_696637 (CHEMBL1641188)
IC50
20000±n/a nM
Citation
 Alvarez, G; Aguirre-López, B; Varela, J; Cabrera, M; Merlino, A; López, GV; Lavaggi, ML; Porcal, W; Di Maio, R; González, M; Cerecetto, H; Cabrera, N; Pérez-Montfort, R; de Gómez-Puyou, MT; Gómez-Puyou, A Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. Eur J Med Chem 45:5767-72 (2010) [PubMed]  Article 
Target
Name:
Triosephosphate isomerase, glycosomal
Synonyms:
TIM | TPIS_TRYCR | Triose-phosphate isomerase
Type:
PROTEIN
Mol. Mass.:
27334.70
Organism:
Trypanosoma cruzi
Description:
ChEMBL_596695
Residue:
251
Sequence:
MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPKFQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAAGFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVATPQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLKPEFVEIIEATK
  
Inhibitor
Name:
BDBM50332792
Synonyms:
4-(5-Nitro-furan-2-ylmethylene)-1,1-dioxo-1,4-dihydro-1lambda*6*-[1,2, 6]thiadiazine-3,5-diamine | CHEMBL1630893
Type:
Small organic molecule
Emp. Form.:
C8H7N5O5S
Mol. Mass.:
285.237
SMILES:
NC1=NS(=O)(=O)NC(=N)C1=Cc1ccc(o1)[N+]([O-])=O |w:10.11,t:1|
Structure:
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