Reaction Details Report a problem with these data
Target
Inositol phosphorylceramide synthase catalytic subunit AUR1
Ligand
BDBM50333120
Substrate
n/a
Meas. Tech.
ChEMBL_690940 (CHEMBL1634548)
IC50
3.8±n/a nM
Citation
 Aeed, PA; Young, CL; Nagiec, MM; Elhammer, AP Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A. Antimicrob Agents Chemother 53:496-504 (2009) [PubMed]  Article 
Target
Name:
Inositol phosphorylceramide synthase catalytic subunit AUR1
Synonyms:
AUR1 | AUR1_YEAST | Aureobasidin A resistance protein | IPC synthase catalytic subunit AUR1 | Phosphatidylinositol:ceramide phosphoinositol transferase
Type:
PROTEIN
Mol. Mass.:
45190.29
Organism:
Saccharomyces cerevisiae S288c
Description:
ChEMBL_690933
Residue:
401
Sequence:
MANPFSRWFLSERPPNCHVADLETSLDPHQTLLKVQKYKPALSDWVHYIFLGSIMLFVFITNPAPWIFKILFYCFLGTLFIIPATSQFFFNALPILTWVALYFTSSYFPDDRRPPITVKVLPAVETILYGDNLSDILATSTNSFLDILAWLPYGLFHFGAPFVVAAILFVFGPPTVLQGYAFAFGYMNLFGVIMQNVFPAAPPWYKILYGLQSANYDMHGSPGGLARIDKLLGINMYTTAFSNSSVIFGAFPSLHSGCATMEALFFCYCFPKLKPLFIAYVCWLWWSTMYLTHHYFVDLMAGSVLSYVIFQYTKYTHLPIVDTSLFCRWSYTSIEKYDISKSDPLAADSNDIESVPLSNLELDFDLNMTDEPSVSPSLFDGSTSVSRSSATSITSLGVKRA
  
Inhibitor
Name:
BDBM50333120
Synonyms:
CHEMBL1631581 | Rustmicin
Type:
Small organic molecule
Emp. Form.:
C22H34O5
Mol. Mass.:
378.5024
SMILES:
CC[C@@H]1CC(=O)[C@H](C)C(=O)[C@@](O)(CO)C\C(OC)=C\[C@@H](C)CC(=C)\C=C1/C |r,t:17,24|
Structure:
Search PDB for entries with ligand similarity: