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Target
DNA polymerase subunit gamma-1
Ligand
BDBM50333127
Substrate
n/a
Meas. Tech.
ChEMBL_695611 (CHEMBL1639859)
IC50
85000±n/a nM
Citation
 Lam, AM; Murakami, E; Espiritu, C; Steuer, HM; Niu, C; Keilman, M; Bao, H; Zennou, V; Bourne, N; Julander, JG; Morrey, JD; Smee, DF; Frick, DN; Heck, JA; Wang, P; Nagarathnam, D; Ross, BS; Sofia, MJ; Otto, MJ; Furman, PA PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother 54:3187-96 (2010) [PubMed]  Article 
Target
Name:
DNA polymerase subunit gamma-1
Synonyms:
DNA Polymerase gamma | DNA nucleotidylexotransferase | DNA polymerase (alpha/delta/epsilon) | DNA polymerase beta | DNA polymerase delta subunit 1 | DNA polymerase eta | DNA polymerase gamma subunit 1 | DNA polymerase iota | DNA polymerase kappa | DNA polymerase lambda | DNA polymerase subunit gamma-1 | DNA-directed DNA/RNA polymerase mu | DPOG1_HUMAN | MDP1 | Mitochondrial DNA polymerase catalytic subunit | POLG | POLG1 | POLGA | PolG-alpha
Type:
Enzyme Subunit
Mol. Mass.:
139566.98
Organism:
Homo sapiens (Human)
Description:
Enzyme was purchased from Ulrich Hubscher, University of Zurich-Irchel, Switzerland.
Residue:
1239
Sequence:
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP
  
Inhibitor
Name:
BDBM50333127
Synonyms:
(beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphate) | CHEMBL1630222
Type:
Small organic molecule
Emp. Form.:
C9H15FN3O12P3
Mol. Mass.:
469.148
SMILES:
Nc1ccn([C@H]2CC[C@H](O2)[C@@H](F)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)c(=O)n1 |r|
Structure:
Search PDB for entries with ligand similarity: