Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50333713
Substrate
n/a
Meas. Tech.
ChEMBL_700443 (CHEMBL1647982)
EC50
600±n/a nM
Citation
Tyagarajan, S; Chakravarty, PK; Park, M; Zhou, B; Herrington, JB; Ratliff, K; Bugianesi, RM; Williams, B; Haedo, RJ; Swensen, AM; Warren, VA; Smith, M; Garcia, M; Kaczorowski, GJ; McManus, OB; Lyons, KA; Li, X; Madeira, M; Karanam, B; Green, M; Forrest, MJ; Abbadie, C; McGowan, E; Mistry, S; Jochnowitz, N; Duffy, JL A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain. Bioorg Med Chem Lett 21:869-73 (2011) [PubMed] Article
More Info.:
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
Inhibitor
Name:
BDBM50333713
Synonyms:
CHEMBL1643739 | N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxo-1-(pyridin-2-yl)ethyl)-1H-indol-5-yl)-2-methylpropanamide
Type:
Small organic molecule
Emp. Form.:
C27H36N4O2
Mol. Mass.:
448.6003
SMILES:
CC(C)(C)NC(=O)C(c1ccccn1)n1ccc2cc(ccc12)C(C)(C)C(=O)NC(C)(C)C