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Target
Growth factor receptor-bound protein 7
Ligand
BDBM50334294
Substrate
n/a
Meas. Tech.
ChEMBL_699661 (CHEMBL1648304)
Kd
5060±n/a nM
Citation
 Ambaye, ND; Gunzburg, MJ; Lim, RC; Price, JT; Wilce, MC; Wilce, JA Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists. Bioorg Med Chem 19:693-701 (2011) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 7
Synonyms:
B47 | Epidermal growth factor receptor GRB-7 | GRB7 | GRB7 adapter protein | GRB7_HUMAN
Type:
PROTEIN
Mol. Mass.:
59700.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_699661
Residue:
532
Sequence:
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
  
Inhibitor
Name:
BDBM50334294
Synonyms:
CHEMBL1642687 | methyl 3-(6-benzoyl-3-hydroxyquinoxalin-2-yl)-5-(2,5-dimethylphenylamino)-2,4,5-trioxopentanoate
Type:
Small organic molecule
Emp. Form.:
C29H23N3O7
Mol. Mass.:
525.5088
SMILES:
COC(=O)C(=O)C(C(=O)C(=O)Nc1cc(C)ccc1C)c1nc2ccc(cc2[nH]c1=O)C(=O)c1ccccc1
Structure:
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