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Target
Growth factor receptor-bound protein 7
Ligand
BDBM50334299
Substrate
n/a
Meas. Tech.
ChEMBL_699661 (CHEMBL1648304)
Kd
17150±n/a nM
Citation
 Ambaye, ND; Gunzburg, MJ; Lim, RC; Price, JT; Wilce, MC; Wilce, JA Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists. Bioorg Med Chem 19:693-701 (2011) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 7
Synonyms:
B47 | Epidermal growth factor receptor GRB-7 | GRB7 | GRB7 adapter protein | GRB7_HUMAN
Type:
PROTEIN
Mol. Mass.:
59700.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_699661
Residue:
532
Sequence:
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
  
Inhibitor
Name:
BDBM50334299
Synonyms:
CHEMBL1642692 | methyl 3-(6-benzoyl-3-hydroxyquinoxalin-2-yl)-5-(2-carbamoylphenylamino)-2,4,5-trioxopentanoate
Type:
Small organic molecule
Emp. Form.:
C28H20N4O8
Mol. Mass.:
540.4804
SMILES:
COC(=O)C(=O)C(C(=O)C(=O)Nc1ccccc1C(N)=O)c1nc2ccc(cc2[nH]c1=O)C(=O)c1ccccc1
Structure:
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