Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-6
Ligand
BDBM50334463
Substrate
n/a
Meas. Tech.
ChEMBL_701134 (CHEMBL1648232)
IC50
0.2±n/a nM
Citation
 Zhang, Z; Zheng, G; Pivavarchyk, M; Deaciuc, AG; Dwoskin, LP; Crooks, PA Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett 21:88-91 (2010) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-6
Synonyms:
ACHA6_RAT | Acra6 | Chrna6 | Neuronal acetylcholine receptor protein alpha-6 subunit | Neuronal acetylcholine receptor subunit alpha-6 | Neuronal acetylcholine receptor subunit alpha-6/beta-3
Type:
PROTEIN
Mol. Mass.:
56943.53
Organism:
Rattus norvegicus
Description:
ChEMBL_1454451
Residue:
493
Sequence:
MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTENSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGAS
  
Inhibitor
Name:
BDBM50334463
Synonyms:
1,3,5-tri-{5-[1-(3-picolinium)]-pent-1-ynyl}benzene tribromide | 1,3,5-tri-{5-[1-(3-picolinium)]-pent-1-ynyl}benzenetribromide | 1-(5-{3,5-bis[5-(3-methylpyridin-1-ium-1-yl)pent-1-yn-1-yl]phenyl}pent-4-yn-1-yl)-3-methylpyridin-1-ium tribromide | CHEMBL239844 | mono(1,1',1''-(5,5',5''-(benzene-1,3,5-triyl)tris(pent-4-yne-5,1-diyl))tris(3-methylpyridinium))tribromide
Type:
Small organic molecule
Emp. Form.:
C39H42N3
Mol. Mass.:
552.7692
SMILES:
Cc1ccc[n+](CCCC#Cc2cc(cc(c2)C#CCCC[n+]2cccc(C)c2)C#CCCC[n+]2cccc(C)c2)c1
Structure:
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