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Target
Cathepsin L2
Ligand
BDBM50336478
Substrate
n/a
Meas. Tech.
ChEMBL_716901 (CHEMBL1670880)
Ki
1100±n/a nM
Citation
 Severino, RP; Guido, RV; Marques, EF; Brömme, D; da Silva, MF; Fernandes, JB; Andricopulo, AD; Vieira, PC Acridone alkaloids as potent inhibitors of cathepsin V. Bioorg Med Chem 19:1477-81 (2011) [PubMed]  Article 
Target
Name:
Cathepsin L2
Synonyms:
CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V
Type:
Enzyme
Mol. Mass.:
37341.06
Organism:
Homo sapiens (Human)
Description:
O60911
Residue:
334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
  
Inhibitor
Name:
BDBM50336478
Synonyms:
1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone | CHEMBL463652 | glycocitrine-IV
Type:
Small organic molecule
Emp. Form.:
C20H21NO5
Mol. Mass.:
355.3844
SMILES:
[#6]-[#8]-c1c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c2c1n(-[#6])c1c(-[#8])cccc1c2=O
Structure:
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