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Target
D-alanyl-D-alanine dipeptidase
Ligand
BDBM50335519
Substrate
n/a
Meas. Tech.
ChEMBL_724225 (CHEMBL1677412)
Ki
62000±n/a nM
Citation
 Hill, CM; Krause, KM; Lewis, SR; Blais, J; Benton, BM; Mammen, M; Humphrey, PP; Kinana, A; Janc, JW Specificity of induction of the vanA and vanB operons in vancomycin-resistant enterococci by telavancin. Antimicrob Agents Chemother 54:2814-8 (2010) [PubMed]  Article 
Target
Name:
D-alanyl-D-alanine dipeptidase
Synonyms:
D-Ala-D-Ala dipeptidase | VANX_ENTFC | Vancomycin B-type resistance protein vanX | vanX
Type:
PROTEIN
Mol. Mass.:
23377.40
Organism:
Enterococcus faecium
Description:
ChEMBL_1350288
Residue:
202
Sequence:
MEIGFTFLDEIVHGVRWDAKYATWDNFTGKPVDGYEVNRIVGTYELAESLLKAKELAATQGYGLLLWDGYRPKRAVNCFMQWAAQPENNLTKESYYPNIDRTEMISKGYVASKSSHSRGSAIDLTLYRLDTGELVPMGSRFDFMDERSHHAANGISCNEAQNRRRLRSIMENSGFEAYSLEWWHYVLRDEPYPNSYFDFPVK
  
Inhibitor
Name:
BDBM50335519
Synonyms:
(S)-3,6-Diamino-hexanoic acid {(3S,9S,12S,15S)-3-((S)-6-hydroxy-2-imino-hexahydro-pyrimidin-4-yl)-9,12-bis-hydroxymethyl-2,5,8,11,14-pentaoxo-6-[1-ureido-meth-(Z)-ylidene]-1,4,7,10,13pentaaza-cyclohexadec-15-yl}-amide | 4-Naphthalen-2-ylmethyl-4,5-dihydro-1H-imidazole | CHEMBL262777 | Chloroorienticin B derivative | Glycopeptide antibiotic | Mannopeptimycin Glycopeptide | Mannopeptimycin glycopeptide analogue | N-demethylvancomycin derivative | Poly ethylene glycol derivative | Tuberactinomycin Analogue | Vancocin | Vancoled | Vancor | Viomycin derivative | vancomycin | vanomycin
Type:
Small organic molecule
Emp. Form.:
C66H75Cl2N9O24
Mol. Mass.:
1449.254
SMILES:
CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C(O)=O)c3O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1)c(Cl)c2 |r|
Structure:
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