Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50121953
Substrate
n/a
Meas. Tech.
ChEMBL_723551 (CHEMBL1676791)
Ki
180±n/a nM
Citation
 Ishii, Y; Eto, M; Mano, Y; Tateda, K; Yamaguchi, K In vitro potentiation of carbapenems with ME1071, a novel metallo-beta-lactamase inhibitor, against metallo-beta-lactamase- producing Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother 54:3625-9 (2010) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM50121953
Synonyms:
2-mercaptoethanecarboxylic acid | 3-mercaptopropanoic acid | 3-mercaptopropionic acid | 3-sulfanylpropanoic acid | 3-thiohydracrylic acid | 3-thiolpropanoic acid | 3-thiopropanoic acid | 3-thiopropionic acid | 3MPA | CHEMBL358697 | beta-mercaptopropionic acid | beta-thiopropionic acid
Type:
Small organic molecule
Emp. Form.:
C3H6O2S
Mol. Mass.:
106.144
SMILES:
OC(=O)CCS
Structure:
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