Reaction Details Report a problem with these data
Target
Placenta growth factor
Ligand
BDBM50339221
Substrate
n/a
Meas. Tech.
ChEMBL_736105 (CHEMBL1692888)
IC50
9000±n/a nM
Citation
 Bower, KE; Lam, SN; Oates, BD; Del Rosario, JR; Corner, E; Osothprarop, TF; Kinhikar, AG; Hoye, JA; Preston, RR; Murphy, RE; Campbell, LA; Huang, H; Jimenez, J; Cao, X; Chen, G; Ainekulu, ZW; Datt, AB; Levin, NJ; Doppalapudi, VR; Pirie-Shepherd, SR; Bradshaw, C; Woodnutt, G; Lappe, RW Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery. J Med Chem 54:1256-65 (2011) [PubMed]  Article 
Target
Name:
Placenta growth factor
Synonyms:
PGF | PGFL | PLGF | PLGF_HUMAN
Type:
PROTEIN
Mol. Mass.:
24794.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942634
Residue:
221
Sequence:
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
  
Inhibitor
Name:
BDBM50339221
Synonyms:
CHEMBL1689447
Type:
Small organic molecule
Emp. Form.:
C85H133N25O20S2
Mol. Mass.:
1889.251
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O |r,wU:125.129,109.113,93.97,81.84,41.42,51.57,66.69,77.106,102.107,4.4,16.25,wD:8.12,37.110,120.125,32.32,58.61,2.2,(3.82,-3.69,;3.82,-5.21,;5.17,-5.99,;6.48,-5.21,;5.16,-7.52,;3.83,-8.3,;2.5,-7.54,;2.5,-6,;1.15,-8.32,;1.17,-9.86,;2.51,-10.64,;3.85,-9.86,;2.51,-12.17,;-.17,-7.55,;-1.52,-8.33,;-1.5,-9.88,;-2.83,-7.56,;-2.84,-6.04,;-1.52,-5.27,;-.19,-6.03,;1.15,-5.25,;1.15,-3.7,;2.46,-2.93,;-.2,-2.92,;-1.52,-3.72,;-4.17,-8.34,;-5.51,-7.58,;-6.84,-8.36,;-5.52,-6.04,;6.51,-8.28,;6.5,-9.83,;7.86,-7.53,;9.19,-8.31,;9.17,-9.86,;10.53,-10.66,;10.51,-12.24,;11.82,-13.06,;11.82,-14.61,;13.16,-15.38,;13.15,-16.93,;11.81,-17.69,;14.48,-17.7,;14.47,-19.25,;13.13,-20.01,;11.68,-19.48,;10.74,-20.7,;11.61,-21.97,;13.09,-21.54,;15.82,-16.94,;17.14,-17.71,;17.14,-19.26,;18.49,-16.95,;19.95,-17.42,;20.86,-16.18,;19.95,-14.94,;18.49,-15.41,;17.16,-14.65,;15.82,-15.42,;17.15,-13.11,;15.81,-12.34,;14.48,-13.12,;13.14,-12.35,;14.48,-14.65,;18.48,-12.33,;18.47,-10.79,;17.13,-10.02,;19.81,-10.01,;21.14,-10.78,;21.15,-12.32,;22.49,-13.08,;23.82,-12.31,;25.16,-13.07,;26.49,-12.29,;25.16,-14.61,;19.83,-8.46,;21.13,-7.69,;22.47,-8.46,;21.12,-6.15,;17.16,-8.43,;15.83,-7.64,;14.49,-8.4,;15.84,-6.1,;17.18,-5.34,;17.19,-3.81,;18.54,-3.06,;18.56,-1.51,;17.23,-.73,;17.24,.81,;15.88,-1.49,;15.87,-3.03,;14.52,-5.31,;13.18,-6.06,;13.16,-7.61,;11.84,-5.28,;11.85,-3.74,;10.52,-2.96,;10.52,-1.4,;9.17,-.61,;9.18,.95,;10.5,-6.04,;10.55,-7.53,;11.9,-8.28,;22.46,-5.37,;22.45,-3.84,;23.79,-6.14,;25.13,-5.36,;10.49,-15.38,;10.49,-16.91,;9.14,-14.6,;7.81,-15.37,;7.81,-16.92,;6.48,-17.69,;6.49,-19.22,;5.14,-20.01,;5.16,-21.57,;3.81,-22.36,;6.52,-22.34,;6.48,-14.61,;6.49,-13.09,;5.19,-15.43,;3.86,-14.64,;3.79,-13.1,;2.52,-15.39,;2.5,-16.96,;1.15,-14.67,;-.16,-15.39,;-.18,-16.99,;-1.51,-17.74,;1.19,-17.71,;-1.52,-14.69,;-2.84,-15.43,;-1.51,-13.12,)|
Structure:
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