Reaction Details Report a problem with these data
Target
Placenta growth factor
Ligand
BDBM50339229
Substrate
n/a
Meas. Tech.
ChEMBL_736105 (CHEMBL1692888)
IC50
5000±n/a nM
Citation
 Bower, KE; Lam, SN; Oates, BD; Del Rosario, JR; Corner, E; Osothprarop, TF; Kinhikar, AG; Hoye, JA; Preston, RR; Murphy, RE; Campbell, LA; Huang, H; Jimenez, J; Cao, X; Chen, G; Ainekulu, ZW; Datt, AB; Levin, NJ; Doppalapudi, VR; Pirie-Shepherd, SR; Bradshaw, C; Woodnutt, G; Lappe, RW Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery. J Med Chem 54:1256-65 (2011) [PubMed]  Article 
Target
Name:
Placenta growth factor
Synonyms:
PGF | PGFL | PLGF | PLGF_HUMAN
Type:
PROTEIN
Mol. Mass.:
24794.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942634
Residue:
221
Sequence:
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
  
Inhibitor
Name:
BDBM50339229
Synonyms:
CHEMBL1689455
Type:
Small organic molecule
Emp. Form.:
C85H129N23O19S3
Mol. Mass.:
1873.271
SMILES:
CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r,wU:85.88,4.4,12.19,32.32,44.52,110.113,62.63,71.72,114.118,92.95,wD:8.8,36.40,23.22,28.28,93.97,99.102,(-.78,-19.3,;.55,-18.52,;.55,-16.98,;1.88,-16.21,;1.88,-14.68,;3.22,-13.91,;4.55,-14.68,;4.55,-16.21,;5.88,-13.91,;7.22,-14.68,;8.55,-13.91,;8.55,-12.37,;9.87,-14.68,;9.87,-16.21,;8.55,-16.98,;8.55,-18.52,;7.2,-19.3,;7.2,-20.85,;5.85,-21.63,;8.55,-21.63,;11.21,-13.92,;12.53,-14.68,;12.53,-16.21,;13.86,-13.91,;13.86,-12.38,;12.55,-11.56,;12.56,-9.99,;11.22,-9.19,;11.24,-7.65,;9.91,-6.88,;8.57,-7.62,;8.57,-9.16,;7.24,-6.87,;5.9,-7.64,;4.59,-6.89,;4.59,-5.36,;3.24,-7.66,;3.26,-9.19,;1.92,-9.98,;.57,-9.22,;1.94,-11.54,;1.93,-6.9,;1.94,-5.34,;3.29,-4.57,;.6,-4.56,;.61,-3,;1.96,-2.23,;3.3,-3.03,;4.65,-2.26,;4.66,-.7,;3.31,.08,;1.96,-.69,;-.75,-5.33,;-2.09,-4.54,;-3.44,-5.31,;-2.08,-2.99,;7.24,-5.35,;8.55,-4.57,;5.9,-4.57,;12.6,-6.88,;13.93,-7.63,;12.54,-5.41,;13.87,-4.63,;13.89,-3.1,;12.57,-2.31,;12.59,-.77,;11.27,.02,;11.29,1.56,;15.21,-5.42,;15.2,-6.95,;16.54,-4.66,;17.86,-5.45,;19.18,-4.71,;19.2,-3.17,;20.46,-2.3,;20.01,-.83,;18.47,-.82,;17.47,.33,;15.97,.03,;15.48,-1.42,;16.49,-2.57,;17.98,-2.26,;17.84,-6.98,;16.51,-7.74,;19.17,-7.76,;23.1,-5.5,;24.44,-4.72,;24.43,-3.2,;25.76,-5.5,;23.12,-7.04,;24.45,-7.8,;21.82,-7.79,;21.8,-9.34,;23.14,-10.12,;23.13,-11.68,;24.49,-9.35,;20.47,-10.12,;19.14,-9.36,;20.49,-11.65,;19.15,-12.43,;17.83,-11.66,;16.49,-12.44,;15.14,-11.66,;16.48,-13.99,;19.16,-13.96,;17.84,-14.72,;20.5,-14.71,;21.95,-14.24,;22.85,-15.48,;21.94,-16.72,;20.49,-16.24,;19.15,-17,;19.14,-18.54,;17.83,-16.24,;16.5,-16.99,;16.48,-18.53,;15.13,-19.29,;13.72,-18.65,;12.67,-19.8,;13.43,-21.15,;14.95,-20.84,;15.18,-16.22,;13.84,-16.98,;15.18,-14.69,;5.87,-12.36,;7.22,-11.58,;4.53,-11.58,;.55,-13.91,;-.78,-14.68,;.55,-12.37,)|
Structure:
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