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Target
L-lactate dehydrogenase A chain
Ligand
BDBM23251
Substrate
n/a
Meas. Tech.
ChEMBL_734826 (CHEMBL1692976)
IC50
10000±n/a nM
Citation
 Granchi, C; Roy, S; Giacomelli, C; Macchia, M; Tuccinardi, T; Martinelli, A; Lanza, M; Betti, L; Giannaccini, G; Lucacchini, A; Funel, N; León, LG; Giovannetti, E; Peters, GJ; Palchaudhuri, R; Calvaresi, EC; Hergenrother, PJ; Minutolo, F Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. J Med Chem 54:1599-612 (2011) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM23251
Synonyms:
1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid | LDHA Inhibitor, 1
Type:
Small organic molecule
Emp. Form.:
C3H2N2O3S
Mol. Mass.:
146.125
SMILES:
OC(=O)c1ns[nH]c1=O
Structure:
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