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Target
Sodium/myo-inositol cotransporter 2
Ligand
BDBM20880
Substrate
n/a
Meas. Tech.
ChEMBL_740127 (CHEMBL1763187)
IC50
380±n/a nM
Citation
 Li, AR; Zhang, J; Greenberg, J; Lee, T; Liu, J Discovery of non-glucoside SGLT2 inhibitors. Bioorg Med Chem Lett 21:2472-5 (2011) [PubMed]  Article 
Target
Name:
Sodium/myo-inositol cotransporter 2
Synonyms:
KST1 | Na(+)/myo-inositol cotransporter 2 | SC5AB_HUMAN | SLC5A11 | SLGTX | SMIT2 | Sodium-dependent glucose cotransporter | Sodium/glucose cotransporter KST1 | Solute carrier family 5 member 11
Type:
PROTEIN
Mol. Mass.:
74036.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_740127
Residue:
675
Sequence:
MESGTSSPQPPQLDPLDAFPQKGLEPGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGISVSAYELNGLFSVLMLAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILAVLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMVSRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGLVRLVLDFIYVQPRCDQPDERPVLVKSIHYLYFSMILSTVTLITVSTVSWFTEPPSKEMVSHLTWFTRHDPVVQKEQAPPAAPLSLTLSQNGMPEASSSSSVQFEMVQENTSKTHSCDMTPKQSKVVKAILWLCGIQEKGKEELPARAEAIIVSLEENPLVKTLLDVNLIFCVSCAIFIWGYFA
  
Inhibitor
Name:
BDBM20880
Synonyms:
(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol | BMS-512148 | C-aryl glucoside, 6 | CHEMBL429910 | Dapagliflozin
Type:
Small organic molecule
Emp. Form.:
C21H25ClO6
Mol. Mass.:
408.873
SMILES:
CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Structure:
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