Reaction Details Report a problem with these data
Target
Cytochrome P450 1A1
Ligand
BDBM50340099
Substrate
n/a
Meas. Tech.
ChEMBL_741097 (CHEMBL1764368)
IC50
1400±n/a nM
Citation
Ratcliffe, P; Adam, JM; Baker, J; Bursi, R; Campbell, R; Clark, JK; Cottney, JE; Deehan, M; Easson, AM; Ecker, D; Edwards, D; Epemolu, O; Evans, L; Fields, R; Francis, S; Harradine, P; Jeremiah, F; Kiyoi, T; McArthur, D; Morrison, A; Passier, P; Pick, J; Schnabel, PG; Schulz, J; Steinbrede, H; Walker, G; Westwood, P; Wishart, G; de Haes, JU Design, synthesis and structure-activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate. Bioorg Med Chem Lett 21:2541-6 (2011) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 1A1
Synonyms:
CP1A1_HUMAN | CYP1A1 | CYPIA1 | Cytochrome P450 1A | Cytochrome P450 1A1 | Cytochrome P450 1A1 (CYP1A1) | P450 form 6 | P450-C | P450-P1
Type:
Protein
Mol. Mass.:
58177.23
Organism:
Homo sapiens (Human)
Description:
P04798
Residue:
512
Sequence:
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
Inhibitor
Name:
BDBM50340099
Synonyms:
2-(((2-(7-chloro-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-indol-3-yl)thiazol-4-yl)methyl)(isopropyl)amino)ethanol | CHEMBL1762808
Type:
Small organic molecule
Emp. Form.:
C23H30ClN3O2S
Mol. Mass.:
448.021
SMILES:
CC(C)N(CCO)Cc1csc(n1)-c1cn(CC2CCOCC2)c2c(Cl)cccc12