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Target
Glucocorticoid receptor
Ligand
BDBM50340666
Substrate
n/a
Meas. Tech.
ChEMBL_739806 (CHEMBL1762866)
IC50
22±n/a nM
Citation
 Hudson, AR; Higuchi, RI; Roach, SL; Valdez, LJ; Adams, ME; Vassar, A; Rungta, D; Syka, PM; Mais, DE; Marschke, KB; Zhi, L Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation. Bioorg Med Chem Lett 21:1654-7 (2011) [PubMed]  Article 
Target
Name:
Glucocorticoid receptor
Synonyms:
GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:
Enzyme
Mol. Mass.:
85656.87
Organism:
Homo sapiens (Human)
Description:
P04150
Residue:
777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
  
Inhibitor
Name:
BDBM50340666
Synonyms:
6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-3-hydroxy-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-methyl oxime | CHEMBL1762211
Type:
Small organic molecule
Emp. Form.:
C20H18ClF2N3O2
Mol. Mass.:
405.826
SMILES:
CO\N=C1/C(O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2c(Cl)c[nH]c12 |(33.75,6.57,;33.74,5.03,;32.41,4.27,;32.4,2.73,;33.73,1.95,;35.07,2.7,;33.72,.41,;35.04,1.19,;35.04,-.36,;32.38,-.35,;31.05,.43,;29.72,-.33,;28.4,.44,;27.07,-.32,;28.41,1.98,;29.74,2.75,;29.74,4.28,;31.06,1.97,;27.08,2.76,;27.08,4.3,;25.75,5.08,;24.42,4.3,;24.41,2.76,;23.26,1.73,;21.92,2.5,;23.89,.32,;25.42,.48,;25.75,1.99,)|
Structure:
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