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Target
Lethal(3)malignant brain tumor-like protein 3
Ligand
BDBM50341828
Substrate
n/a
Meas. Tech.
ChEMBL_743620 (CHEMBL1768163)
IC50
35000±n/a nM
Citation
 Herold, JM; Wigle, TJ; Norris, JL; Lam, R; Korboukh, VK; Gao, C; Ingerman, LA; Kireev, DB; Senisterra, G; Vedadi, M; Tripathy, A; Brown, PJ; Arrowsmith, CH; Jin, J; Janzen, WP; Frye, SV Small-molecule ligands of methyl-lysine binding proteins. J Med Chem 54:2504-11 (2011) [PubMed]  Article 
Target
Name:
Lethal(3)malignant brain tumor-like protein 3
Synonyms:
H-l(3)mbt-like protein 3 | KIAA1798 | L(3)mbt-like protein 3 | L3MBTL3 | LMBL3_HUMAN | Lethal(3)malignant brain tumor-like protein 3 | Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) | MBT-1 | MBT1
Type:
Protein
Mol. Mass.:
88334.17
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
780
Sequence:
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRLSGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREEPTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
  
Inhibitor
Name:
BDBM50341828
Synonyms:
3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbonyl]pyridine | 5-Bromo-N-(4-(pyrrolidinyl)piperidinyl)nicotinamide | CHEMBL1235119
Type:
Small organic molecule
Emp. Form.:
C15H20BrN3O
Mol. Mass.:
338.243
SMILES:
Brc1cncc(c1)C(=O)N1CCC(CC1)N1CCCC1
Structure:
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