Reaction Details Report a problem with these data
Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50341982
Substrate
n/a
Meas. Tech.
ChEMBL_743570 (CHEMBL1768070)
Ki
150±n/a nM
Citation
 Vintonyak, VV; Waldmann, H; Rauh, D Using small molecules to target protein phosphatases. Bioorg Med Chem 19:2145-55 (2011) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50341982
Synonyms:
5-(2-cyclohexyl-4-((1-(6-(4-fluoro-2-methylphenylsulfonamido)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)isoxazole-3-carboxylic acid | CHEMBL1765363
Type:
Small organic molecule
Emp. Form.:
C32H38FN5O6S
Mol. Mass.:
639.737
SMILES:
Cc1cc(F)ccc1S(=O)(=O)NCCCCCCn1cc(COc2ccc(-c3cc(no3)C(O)=O)c(c2)C2CCCCC2)nn1
Structure:
Search PDB for entries with ligand similarity: