Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50342750
Substrate
n/a
Meas. Tech.
ChEMBL_744276 (CHEMBL1772083)
IC50
290±n/a nM
Citation
 Tang, W; Luo, T; Greenberg, EF; Bradner, JE; Schreiber, SL Discovery of histone deacetylase 8 selective inhibitors. Bioorg Med Chem Lett 21:2601-5 (2011) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50342750
Synonyms:
CHEMBL1771484 | N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)hydrazinyl)octanamide
Type:
Small organic molecule
Emp. Form.:
C18H23N3O4
Mol. Mass.:
345.3929
SMILES:
ONC(=O)CCCCCCC(=O)NN=Cc1ccc(OCC#C)cc1 |w:14.14|
Structure:
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