Reaction Details Report a problem with these data
Target
Uracil-DNA glycosylase
Ligand
BDBM50343396
Substrate
n/a
Meas. Tech.
ChEMBL_747132 (CHEMBL1777498)
IC50
139100±n/a nM
Citation
 Nuth, M; Huang, L; Saw, YL; Schormann, N; Chattopadhyay, D; Ricciardi, RP Identification of inhibitors that block vaccinia virus infection by targeting the DNA synthesis processivity factor D4. J Med Chem 54:3260-7 (2011) [PubMed]  Article 
Target
Name:
Uracil-DNA glycosylase
Synonyms:
OPG116 | UDG | UNG | UNG_VACCW
Type:
PROTEIN
Mol. Mass.:
25071.48
Organism:
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strainWR))
Description:
ChEMBL_747132
Residue:
218
Sequence:
MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDYSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKAPINWAQGFIY
  
Inhibitor
Name:
BDBM50343396
Synonyms:
CHEMBL1551959 | ethyl 4-(4-(dimethylamino)phenylamino)benzo[h]quinoline-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C24H23N3O2
Mol. Mass.:
385.4583
SMILES:
CCOC(=O)c1cnc2c(ccc3ccccc23)c1Nc1ccc(cc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: