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Target
Muscle, skeletal receptor tyrosine-protein kinase
Ligand
BDBM50343726
Substrate
n/a
Meas. Tech.
ChEMBL_746726 (CHEMBL1776851)
IC50
224±n/a nM
Citation
 Wang, T; Ioannidis, S; Almeida, L; Block, MH; Davies, AM; Lamb, ML; Scott, DA; Su, M; Zhang, HJ; Alimzhanov, M; Bebernitz, G; Bell, K; Zinda, M In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett 21:2958-61 (2011) [PubMed]  Article 
Target
Name:
Muscle, skeletal receptor tyrosine-protein kinase
Synonyms:
MUSK | MUSK_HUMAN | Muscle, skeletal receptor tyrosine protein kinase
Type:
PROTEIN
Mol. Mass.:
97062.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1474077
Residue:
869
Sequence:
MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV
  
Inhibitor
Name:
BDBM50343726
Synonyms:
(S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile | CHEMBL1774056
Type:
Small organic molecule
Emp. Form.:
C17H15F2N7
Mol. Mass.:
355.3447
SMILES:
C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(F)cc1C#N)c1ccc(F)cn1 |r|
Structure:
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