Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50344147
Substrate
n/a
Meas. Tech.
ChEMBL_748047 (CHEMBL1781588)
EC50
>10000±n/a nM
Citation
Pike, KG; Allen, JV; Caulkett, PW; Clarke, DS; Donald, CS; Fenwick, ML; Johnson, KM; Johnstone, C; McKerrecher, D; Rayner, JW; Walker, RP; Wilson, I Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life. Bioorg Med Chem Lett 21:3467-70 (2011) [PubMed] Article
More Info.:
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Inhibitor
Name:
BDBM50344147
Synonyms:
(S)-6-(3-(1-methoxy-2-methylpropan-2-yloxy)-5-(1-phenylpropan-2-yloxy)benzamido)nicotinic acid | CHEMBL1778359
Type:
Small organic molecule
Emp. Form.:
C27H30N2O6
Mol. Mass.:
478.5369
SMILES:
COCC(C)(C)Oc1cc(O[C@@H](C)Cc2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O |r|