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Target
Natriuretic peptides A
Ligand
BDBM50344187
Substrate
n/a
Meas. Tech.
ChEMBL_748204 (CHEMBL1780285)
IC50
1.5±n/a nM
Citation
 Glossop, MS; Bazin, RJ; Dack, KN; Fox, DN; MacDonald, GA; Mills, M; Owen, DR; Phillips, C; Reeves, KA; Ringer, TJ; Strang, RS; Watson, CA Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors. Bioorg Med Chem Lett 21:3404-6 (2011) [PubMed]  Article 
Target
Name:
Natriuretic peptides A
Synonyms:
ANF | ANF_HUMAN | ANP | Atrial natriuretic factor | Atrial natriuretic peptide | CDD-ANF | CDP | Cardiodilatin-related peptide | NPPA | Natriuretic peptides A | PND | Prepronatriodilatin
Type:
PROTEIN
Mol. Mass.:
16393.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_748204
Residue:
151
Sequence:
MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY
  
Inhibitor
Name:
BDBM50344187
Synonyms:
(S)-2-((S)-1-((S)-2-(biphenyl-4-yl)-1-carboxyethylamino)-5-methyl-1-oxohexan-2-ylamino)-4-phenylbutanoic acid | CHEMBL1778526
Type:
Small organic molecule
Emp. Form.:
C32H38N2O5
Mol. Mass.:
530.6545
SMILES:
CC(C)CC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O |r|
Structure:
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