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Target
Synaptic vesicular amine transporter
Ligand
BDBM50301021
Substrate
n/a
Meas. Tech.
ChEMBL_747720 (CHEMBL1780875)
Ki
1.03±n/a nM
Citation
 Zheng, P; Lieberman, BP; Choi, SR; Plöessl, K; Kung, HF Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands. Bioorg Med Chem Lett 21:3435-8 (2011) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2
Type:
Protein
Mol. Mass.:
55689.58
Organism:
Rattus norvegicus (Rat)
Description:
Q01827
Residue:
515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
  
Inhibitor
Name:
BDBM50301021
Synonyms:
(+)-dihydrotetrabenzaine | CHEMBL576222 | US11053242, Compound R,R,R-DHTBZ
Type:
Small organic molecule
Emp. Form.:
C19H29NO3
Mol. Mass.:
319.4385
SMILES:
COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC |r|
Structure:
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