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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50344485
Substrate
n/a
Meas. Tech.
ChEMBL_747850 (CHEMBL1781105)
EC50
403±n/a nM
Citation
 Xia, Y; Chackalamannil, S; Greenlee, WJ; Jayne, C; Neustadt, B; Stamford, A; Vaccaro, H; Xu, XL; Baker, H; O'Neill, K; Woods, M; Hawes, B; Kowalski, T Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes. Bioorg Med Chem Lett 21:3290-6 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_MOUSE | Gpr119
Type:
PROTEIN
Mol. Mass.:
37009.07
Organism:
Mus musculus
Description:
ChEMBL_1506420
Residue:
335
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
  
Inhibitor
Name:
BDBM50344485
Synonyms:
CHEMBL1778140 | isopropyl 4-(6-(2-fluoro-4-(methylsulfonyl)phenoxy)pyrimidin-4-yloxy)piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H24FN3O6S
Mol. Mass.:
453.484
SMILES:
CC(C)OC(=O)N1CCC(CC1)Oc1cc(Oc2ccc(cc2F)S(C)(=O)=O)ncn1
Structure:
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