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Target
Serine/threonine-protein kinase ICK
Ligand
BDBM50346243
Substrate
n/a
Meas. Tech.
ChEMBL_749968 (CHEMBL1786945)
IC50
>10000±n/a nM
Citation
 Blackburn, C; Duffey, MO; Gould, AE; Kulkarni, B; Liu, JX; Menon, S; Nagayoshi, M; Vos, TJ; Williams, J Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors. Bioorg Med Chem Lett 20:4795-9 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase ICK
Synonyms:
CILK1 | CILK1_HUMAN | ICK | Intestinal cell kinase | KIAA0936 | LCK2 | Laryngeal cancer kinase 2 | MAK-related kinase | MRK | hICK
Type:
PROTEIN
Mol. Mass.:
71470.23
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774570
Residue:
632
Sequence:
MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLSGKSSGTMSVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRTDWASKYASRR
  
Inhibitor
Name:
BDBM50346243
Synonyms:
CHEMBL1779593 | furan-2-yl(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone | rac-furan-2-yl(5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
Type:
Small organic molecule
Emp. Form.:
C19H15N3O3
Mol. Mass.:
333.3407
SMILES:
Oc1ccccc1C1CC(=NN1C(=O)c1ccco1)c1cccnc1 |c:10|
Structure:
Search PDB for entries with ligand similarity: