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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50346447
Substrate
n/a
Meas. Tech.
ChEMBL_751314 (CHEMBL1787992)
IC50
57810±n/a nM
Citation
 Berrade, L; Aisa, B; Ramirez, MJ; Galiano, S; Guccione, S; Moltzau, LR; Levy, FO; Nicoletti, F; Battaglia, G; Molinaro, G; Aldana, I; Monge, A; Perez-Silanes, S Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. J Med Chem 54:3086-90 (2011) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50346447
Synonyms:
4-[4-(3-benzo[b]thiophen-3-yl-3-hydroxypropyl)-[1,4]-diazepan-1-yl]benzonitrile | CHEMBL1782809
Type:
Small organic molecule
Emp. Form.:
C23H25N3OS
Mol. Mass.:
391.529
SMILES:
OC(CCN1CCCN(CC1)c1ccc(cc1)C#N)c1csc2ccccc12
Structure:
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