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Target
Beta-lactamase SHV-5
Ligand
BDBM50347181
Substrate
n/a
Meas. Tech.
ChEMBL_754353 (CHEMBL1799219)
IC50
25000±n/a nM
Citation
 Tan, Q; Ogawa, AM; Raghoobar, SL; Wisniewski, D; Colwell, L; Park, YW; Young, K; Hermes, JD; Dininno, FP; Hammond, ML Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii. Bioorg Med Chem Lett 21:4363-5 (2011) [PubMed]  Article 
Target
Name:
Beta-lactamase SHV-5
Synonyms:
BLA5_KLEPN | bla | shv5
Type:
PROTEIN
Mol. Mass.:
31257.78
Organism:
Klebsiella pneumoniae
Description:
ChEMBL_754353
Residue:
286
Sequence:
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
  
Inhibitor
Name:
BDBM50347181
Synonyms:
CHEMBL1795564
Type:
Small organic molecule
Emp. Form.:
C16H12Cl3FN5O6PS
Mol. Mass.:
558.693
SMILES:
CO\N=C(/C(=O)NCP(O)(=O)Oc1ccc(C#N)c(F)c1)c1cnc(NC(=O)C(Cl)(Cl)Cl)s1
Structure:
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