Reaction Details Report a problem with these data
Target
Elongation factor 1-alpha 1
Ligand
BDBM50347601
Substrate
n/a
Meas. Tech.
ChEMBL_756745 (CHEMBL1805291)
Kd
3.74±n/a nM
Citation
 Yao, N; Chen, CY; Wu, CY; Motonishi, K; Kung, HJ; Lam, KS Novel flavonoids with antiproliferative activities against breast cancer cells. J Med Chem 54:4339-49 (2011) [PubMed]  Article 
Target
Name:
Elongation factor 1-alpha 1
Synonyms:
EEF1A | EEF1A1 | EF-1-alpha-1 | EF-Tu | EF1A | EF1A1_HUMAN | Elongation factor Tu | Eukaryotic elongation factor 1 A-1 | LENG7 | Leukocyte receptor cluster member 7 | eEF1A-1
Type:
PROTEIN
Mol. Mass.:
50156.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_756745
Residue:
462
Sequence:
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
  
Inhibitor
Name:
BDBM50347601
Synonyms:
CHEMBL1802814
Type:
Small organic molecule
Emp. Form.:
C38H43N5O5
Mol. Mass.:
649.7785
SMILES:
COc1ccc(Nc2nc3cc4c(cc3n2[C@H](C)C2CCCCC2)oc(cc4=O)-c2ccc(cc2)C(=O)N[C@@H](CC(C)C)C(N)=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: