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Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Ligand
BDBM50181153
Substrate
n/a
Meas. Tech.
ChEMBL_767067 (CHEMBL1826116)
IC50
160±n/a nM
Citation
 Andaloussi, M; Lindh, M; Björkelid, C; Suresh, S; Wieckowska, A; Iyer, H; Karlén, A; Larhed, M Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett 21:5403-7 (2011) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms:
DXR_MYCTU | dxr
Type:
PROTEIN
Mol. Mass.:
42846.92
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_1474510
Residue:
413
Sequence:
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
  
Inhibitor
Name:
BDBM50181153
Synonyms:
3-(N-hydroxyacetamido)propylphosphonic acid | 3-(N-hydroxyformamido)propylphosphonic acid | CHEMBL205338 | FR-900098 | ammonium 3-(N-hydroxyacetamido)propylphosphonate
Type:
Small organic molecule
Emp. Form.:
C5H12NO5P
Mol. Mass.:
197.1262
SMILES:
CC(=O)N(O)CCCP(O)(O)=O
Structure:
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