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Target
Branched-chain-amino-acid aminotransferase, cytosolic
Ligand
BDBM50353005
Substrate
n/a
Meas. Tech.
ChEMBL_767755 (CHEMBL1825867)
IC50
230±n/a nM
Citation
 Mendoza, R; Petros, AM; Liu, Y; Thimmapaya, R; Surowy, CS; Leise, WF; Pereda-Lopez, A; Panchal, SC; Sun, C Cracking the molecular weight barrier: fragment screening of an aminotransferase using an NMR-based functional assay. Bioorg Med Chem Lett 21:5248-50 (2011) [PubMed]  Article 
Target
Name:
Branched-chain-amino-acid aminotransferase, cytosolic
Synonyms:
BCAT1 | BCAT1_HUMAN | BCT1 | Branched-chain-amino-acid transferase | ECA39
Type:
PROTEIN
Mol. Mass.:
42957.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1516919
Residue:
386
Sequence:
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS
  
Inhibitor
Name:
BDBM50353005
Synonyms:
CHEMBL1231666
Type:
Small organic molecule
Emp. Form.:
C16H10ClF3N2O4S
Mol. Mass.:
418.775
SMILES:
FC(F)(F)c1ccccc1S(=O)(=O)NNC(=O)c1cc2cc(Cl)ccc2o1
Structure:
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