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Target
Cyclin-dependent kinase 1
Ligand
BDBM10838
Substrate
n/a
Meas. Tech.
ChEMBL_769743 (CHEMBL1831549)
IC50
2500±n/a nM
Citation
 Lebar, MD; Hahn, KN; Mutka, T; Maignan, P; McClintock, JB; Amsler, CD; van Olphen, A; Kyle, DE; Baker, BJ CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs. Bioorg Med Chem 19:5756-62 (2011) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM10838
Synonyms:
3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridianin A
Type:
Small organic molecule
Emp. Form.:
C12H10N4O
Mol. Mass.:
226.234
SMILES:
Nc1nccc(n1)-c1c[nH]c2cccc(O)c12
Structure:
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