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Target
Cystine/glutamate transporter
Ligand
BDBM50355007
Substrate
n/a
Meas. Tech.
ChEMBL_772170 (CHEMBL1838227)
IC50
75000±n/a nM
Citation
 Shukla, K; Thomas, AG; Ferraris, DV; Hin, N; Sattler, R; Alt, J; Rojas, C; Slusher, BS; Tsukamoto, T Inhibition of xc¿?¿ transporter-mediated cystine uptake by sulfasalazine analogs. Bioorg Med Chem Lett 21:6184-7 (2011) [PubMed]  Article 
Target
Name:
Cystine/glutamate transporter
Synonyms:
SLC7A11 | XCT_HUMAN
Type:
PROTEIN
Mol. Mass.:
55437.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_772170
Residue:
501
Sequence:
MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEVVPEEDKL
  
Inhibitor
Name:
BDBM50355007
Synonyms:
CHEMBL1834959
Type:
Small organic molecule
Emp. Form.:
C20H14N2O4S
Mol. Mass.:
378.401
SMILES:
OC(=O)c1cccc(c1)C#Cc1ccc(cc1)S(=O)(=O)Nc1ccccn1
Structure:
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