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Target
B1 bradykinin receptor
Ligand
BDBM50355058
Substrate
n/a
Meas. Tech.
ChEMBL_772771 (CHEMBL1837510)
IC50
17.5±n/a nM
Citation
 Biswas, K; Peterkin, TA; Bryan, MC; Arik, L; Lehto, SG; Sun, H; Hsieh, FY; Xu, C; Fremeau, RT; Allen, JR Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists. J Med Chem 54:7232-46 (2011) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
BDKRB1 | BKRB1_RABIT | Bradykinin B1 receptor
Type:
PROTEIN
Mol. Mass.:
39519.62
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_796432
Residue:
352
Sequence:
MASQGPLELQPSNQSQLAPPNATSCSGAPDAWDLLHRLLPTFIIAIFTLGLLGNSFVLSVFLLARRRLSVAEIYLANLAASDLVFVLGLPFWAENVRNQFDWPFGAALCRIVNGVIKANLFISIFLVVAISQDRYSVLVHPMASRRGRRRRQAQATCALIWLAGGLLSTPTFVLRSVRAVPELNVSACILLLPHEAWHWLRMVELNLLGFLLPLAAILFFNCHILASLRRRGERVPSRCGGPRDSKSTALILTLVASFLVCWAPYHFFAFLECLWQVHAIGGCFWEEFTDLGLQLSNFSAFVNSCLNPVIYVFVGRLFRTKVWELCQQCSPRSLAPVSSSRRKEMLWGFWRN
  
Inhibitor
Name:
BDBM50355058
Synonyms:
CHEMBL1834750
Type:
Small organic molecule
Emp. Form.:
C31H31ClN4O3
Mol. Mass.:
543.056
SMILES:
Cc1nn(-c2ccc(cc2)C(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc23)c(=O)c2c(Cl)cccc12 |r|
Structure:
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