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Target
Dual specificity mitogen-activated protein kinase kinase 3
Ligand
BDBM25084
Substrate
n/a
Meas. Tech.
ChEMBL_774374 (CHEMBL1908591)
Kd
6600±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 3
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 3 | MAP kinase kinase 3 | MAP2K3 | MAPK/ERK kinase 3 | MAPK/ERK kinase 3 (MEK3) | MAPKK 3 | MEK3 | MKK3 | MP2K3_HUMAN | PRKMK3 | SKK2
Type:
Protein
Mol. Mass.:
39321.50
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
347
Sequence:
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
  
Inhibitor
Name:
BDBM25084
Synonyms:
3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol | JMC504279 Compound 6 | TG100-115
Type:
Small organic molecule
Emp. Form.:
C18H14N6O2
Mol. Mass.:
346.3428
SMILES:
Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Structure:
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