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Target
Renin
Ligand
BDBM50355509
Substrate
n/a
Meas. Tech.
ChEMBL_776557 (CHEMBL1913654)
IC50
0.03±n/a nM
Citation
 Chen, A; Cauchon, E; Chefson, A; Dolman, S; Ducharme, Y; Dubé, D; Falgueyret, JP; Fournier, PA; Gagné, S; Gallant, M; Grimm, E; Han, Y; Houle, R; Huang, JQ; Hughes, G; Jûteau, H; Lacombe, P; Lauzon, S; Lévesque, JF; Liu, S; Macdonald, D; Mackay, B; McKay, D; Percival, MD; St-Jacques, R; Toulmond, S Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines. Bioorg Med Chem Lett 21:3976-81 (2011) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50355509
Synonyms:
CHEMBL1910311
Type:
Small organic molecule
Emp. Form.:
C28H28F3N5O3
Mol. Mass.:
539.5488
SMILES:
Cc1noc(Cn2cc(CN(C3CC3)C(=O)[C@H]3CNCC[C@]3(O)c3ccc(F)c(F)c3)c3c(F)cccc23)n1 |r|
Structure:
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