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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50355910
Substrate
n/a
Meas. Tech.
ChEMBL_775908 (CHEMBL1912881)
IC50
4000±n/a nM
Citation
 Kassis, P; Brzeszcz, J; Bénéteau, V; Lozach, O; Meijer, L; Le Guével, R; Guillouzo, C; Lewinski, K; Bourg, S; Colliandre, L; Routier, S; Mérour, JY Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents. Eur J Med Chem 46:5416-34 (2011) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3
Type:
PROTEIN
Mol. Mass.:
46774.42
Organism:
Sus scrofa
Description:
ChEMBL_939732
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
  
Inhibitor
Name:
BDBM50355910
Synonyms:
CHEMBL1910196
Type:
Small organic molecule
Emp. Form.:
C20H13N3O
Mol. Mass.:
311.3367
SMILES:
Oc1ccc2cc([nH]c2c1)-c1cncc(c1)-c1ccc(cc1)C#N
Structure:
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