Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50356546
Substrate
n/a
Meas. Tech.
ChEMBL_776030 (CHEMBL1912500)
Ki
136.3±n/a nM
Citation
 Piscitelli, F; Ligresti, A; La Regina, G; Gatti, V; Brizzi, A; Pasquini, S; Allarà, M; Carai, MA; Novellino, E; Colombo, G; Di Marzo, V; Corelli, F; Silvestri, R 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands. Eur J Med Chem 46:5641-53 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50356546
Synonyms:
CHEMBL1909854
Type:
Small organic molecule
Emp. Form.:
C25H30Cl2N4O
Mol. Mass.:
473.438
SMILES:
CCc1ccc(CC)n1-c1c(C)c(nn1-c1ccc(Cl)c(Cl)c1)C(=O)NC1CCCCC1 |(32.01,-22.38,;33.33,-23.17,;33.3,-24.71,;32.04,-25.6,;32.5,-27.07,;34.04,-27.09,;34.92,-28.36,;34.27,-29.75,;34.54,-25.64,;36.01,-25.19,;36.49,-23.73,;35.58,-22.48,;38.02,-23.73,;38.5,-25.19,;37.25,-26.09,;37.25,-27.63,;35.91,-28.4,;35.91,-29.94,;37.24,-30.71,;37.24,-32.25,;38.58,-29.93,;39.91,-30.7,;38.58,-28.4,;38.93,-22.49,;38.31,-21.08,;40.46,-22.65,;41.37,-21.4,;42.89,-21.58,;43.8,-20.34,;43.18,-18.93,;41.65,-18.76,;40.73,-20.01,)|
Structure:
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