Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50356545
Substrate
n/a
Meas. Tech.
ChEMBL_776031 (CHEMBL1912501)
Ki
>10000±n/a nM
Citation
 Piscitelli, F; Ligresti, A; La Regina, G; Gatti, V; Brizzi, A; Pasquini, S; Allarà, M; Carai, MA; Novellino, E; Colombo, G; Di Marzo, V; Corelli, F; Silvestri, R 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands. Eur J Med Chem 46:5641-53 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50356545
Synonyms:
CHEMBL1909853
Type:
Small organic molecule
Emp. Form.:
C26H24Cl4N4O
Mol. Mass.:
550.307
SMILES:
CCc1ccc(CC)n1-c1c(C)c(nn1-c1ccc(Cl)c(Cl)c1)C(=O)NCc1ccc(Cl)c(Cl)c1 |(16.16,-22.57,;17.49,-23.36,;17.46,-24.9,;16.2,-25.79,;16.65,-27.26,;18.19,-27.28,;19.08,-28.54,;18.43,-29.94,;18.69,-25.83,;20.17,-25.38,;20.64,-23.92,;19.74,-22.67,;22.18,-23.92,;22.65,-25.38,;21.41,-26.28,;21.4,-27.82,;20.07,-28.58,;20.06,-30.12,;21.4,-30.9,;21.4,-32.44,;22.74,-30.12,;24.07,-30.89,;22.73,-28.58,;23.09,-22.67,;22.46,-21.27,;24.62,-22.84,;25.53,-21.59,;27.07,-21.59,;27.84,-22.92,;29.38,-22.92,;30.15,-21.58,;31.69,-21.58,;29.37,-20.25,;30.13,-18.91,;27.83,-20.25,)|
Structure:
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