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Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50343931
Substrate
n/a
Meas. Tech.
ChEMBL_796246 (CHEMBL1937561)
Ki
698±n/a nM
Citation
 Tanino, T; Al-Dabbagh, B; Mengin-Lecreulx, D; Bouhss, A; Oyama, H; Ichikawa, S; Matsuda, A Mechanistic analysis of muraymycin analogues: a guide to the design of MraY inhibitors. J Med Chem 54:8421-39 (2011) [PubMed]  Article 
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_BACSU | mraY
Type:
PROTEIN
Mol. Mass.:
35531.14
Organism:
Bacillus subtilis
Description:
ChEMBL_796247
Residue:
324
Sequence:
MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKSHQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIKVVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVLFMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFLVFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFKTTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL
  
Inhibitor
Name:
BDBM50343931
Synonyms:
(2S,6S,9R,16S)-16-((S)-((2S,3R,4S,5R)-5-(aminomethyl)-3,4-dihydroxytetrahydrofuran-2-yloxy)((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-6-((S)-2-iminohexahydropyrimidin-4-yl)-2-isopropyl-4,7,10-trioxo-9-pentadecyl-3,5,8,11,15-pentaazaheptadecane-1,17-dioic acid | CHEMBL1780219
Type:
Small organic molecule
Emp. Form.:
C48H83N11O16
Mol. Mass.:
1070.2367
SMILES:
CCCCCCCCCCCCCCC[C@@H](NC(=O)[C@@H](NC(=O)N[C@@H](C(C)C)C(O)=O)[C@@H]1CCN=C(N)N1)C(=O)NCCCN[C@@H]([C@H](O[C@@H]1O[C@H](CN)[C@@H](O)[C@H]1O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)C(O)=O |r,t:34|
Structure:
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