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Target
B1 bradykinin receptor
Ligand
BDBM50355083
Substrate
n/a
Meas. Tech.
ChEMBL_796432 (CHEMBL1937747)
IC50
>6465±n/a nM
Citation
 Bryan, MC; Biswas, K; Peterkin, TA; Rzasa, RM; Arik, L; Lehto, SG; Sun, H; Hsieh, FY; Xu, C; Fremeau, RT; Allen, JR Chromenones as potent bradykinin B1 antagonists. Bioorg Med Chem Lett 22:619-22 (2011) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
BDKRB1 | BKRB1_RABIT | Bradykinin B1 receptor
Type:
PROTEIN
Mol. Mass.:
39519.62
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_796432
Residue:
352
Sequence:
MASQGPLELQPSNQSQLAPPNATSCSGAPDAWDLLHRLLPTFIIAIFTLGLLGNSFVLSVFLLARRRLSVAEIYLANLAASDLVFVLGLPFWAENVRNQFDWPFGAALCRIVNGVIKANLFISIFLVVAISQDRYSVLVHPMASRRGRRRRQAQATCALIWLAGGLLSTPTFVLRSVRAVPELNVSACILLLPHEAWHWLRMVELNLLGFLLPLAAILFFNCHILASLRRRGERVPSRCGGPRDSKSTALILTLVASFLVCWAPYHFFAFLECLWQVHAIGGCFWEEFTDLGLQLSNFSAFVNSCLNPVIYVFVGRLFRTKVWELCQQCSPRSLAPVSSSRRKEMLWGFWRN
  
Inhibitor
Name:
BDBM50355083
Synonyms:
CHEMBL1835762
Type:
Small organic molecule
Emp. Form.:
C32H34N4O2
Mol. Mass.:
506.638
SMILES:
Cc1nn(-c2cccc(c2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2ccccc12 |r|
Structure:
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